“This Is Us” stars Mandy Moore and Justin Hartley (ex-Adam Newman, “The Young and the Restless”) will be co-hosting NBC’s “Red Nose Day Special,” the network announced Monday.

Airing on Thursday, May 21 at 9:00 p.m. ET/PT on the network, the two will be joined by an all-star cast of Hollywood and music favorites coming together to have fun, raise money and change lives. The two-hour television event raises awareness and life-changing funds for children in need in all 50 states, Puerto Rico and some of the world’s poorest communities.

Marking its sixth annual tradition will be Julia Roberts, Kelly Clarkson, John Legend, Paul Rudd, 5 Seconds of Summer, Elizabeth Banks, Jennifer Garner, Ricky Gervais, Joel McHale, Stephen Merchant, Sarah Silverman and Susan Kelechi-Watson, among others, as the special campaign seeks to help end child poverty.

Previously announced stars appearing include Bryan Cranston, Blake Shelton, Gwen Stefani, OneRepublic, Jim Gaffigan, Ellie Goulding, Tony Hale, Noah Jupe, Mario Lopez, Steve Martin and the Steep Canyon Rangers, Ray Romano, Lilly Singh, Sam Smith, James Taylor, Meghan Trainor, Milo Ventimiglia and Adrienne Warren (the star of “Tina: The Tina Turner Musical”).

In addition to the unforgettable music performances and original sketches, viewers will also see short compelling films that show how donations to Red Nose Day are used to change and save the lives of children living in poverty across America and around the world.

In light of the health crisis, Red Nose Day’s iconic Red Noses will not be sold in Walgreens stores this year. Instead, Red Nose Day and Walgreens teamed up to create this year’s new digital Red Nose that offers an easy, fun way for the public to participate in the annual campaign, even while staying at home. Supporters can go to NosesOn.com to donate and unlock their own digital Red Nose and share their #NosesOn selfies on Facebook, Snapchat and Instagram to show their support for children in need, and encourage others to donate. People can also support the cause by organizing virtual fundraising events with friends, co-workers or community members, and tuning in to donate and watch the star-studded night of programming.

For more information, visit RedNoseDay.org.