This week on “General Hospital,” it’s the moment fans have been clamoring for when someone finally decides they’ve had enough of Drew Cain (Cameron Mathison), resulting in the congressman being shot by an unknown assailant.
Note: “General Hospital” aired a rerun on Monday, September 1 (Labor Day). The show returns with all-new episodes on Tuesday, September 2.
In a promo released for the daytime drama series for the week of September 1-5, 2025, Anna Devane (Finola Hughes) can be seen asking Dante Falconeri (Dominic Zamprogna), “How many people do you think want Drew Cain dead?” Dante responds, saying, “That’s a long list!”

Agreeing with Dante’s assessment, Anna ponders, “Who’s at the top?” as several faces flash across the screen, including that of Portia (Brook Kerr), Sonny (Maurice Benard), Willow (Katelyn MacMullen), Curtis (Donnell Turner), Nina (Cynthia Watros) and Michael (Rory Gibson). However, as Dante said, the list of suspects is quite long, as outlined by user @port_misery in a post on X (formerly Twitter), which displays a collage of several dozen people in Port Charles who would have wanted to off the former Quartermaine.
Check out this week’s promo below.
Interestingly, one potential suspect, Carly Spencer (Laura Wright), metaphorically has wanted to get back at Drew for some time, as she once said to Jason (Steve Burton) in December 2024, “You had your shot at Drew… let me have mine!” Could she have finally reached her breaking point?
On Monday, September 8, “General Hospital” kicks off its 63rd season on ABC.
To find out how the story develops, make sure to watch “General Hospital” weekdays on ABC. Stream anytime on Hulu.




